Restricted Access to Myeloid Cells Explained

Viruses

关键词: Vpx;    DCAF-1;    SAMHD1;    ubiquitin;    Cullin4;    HIV;    SIV;    macrophage;    dendritic cell;    myeloid cell;   

DOI  :  10.3390/v3091624

来源: mdpi

【 摘 要 】

The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.