Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

Molecules

Ana Silvia Suassuna Carneiro Lúcio¹  Jackson Roberto Guedes Da Silva Almeida¹  José Maria Barbosa-Filho¹  João Carlos Lima Rodrigues Pita¹  Marianna Vieira Sobral Castello Branco¹  Margareth De Fátima Formiga Melo Diniz¹  Maria De Fátima Agra¹  Emidio V.L. Da-Cunha¹  Marcelo Sobral Da Silva¹ 

[1] ¹Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa, PB, Brazil ²Academic Collegiate of Pharmaceutical Sciences, Federal University of Sao Francisco Valley, P.O. Box 252, 56306-410, Petrolina, PE, Brazil ³State University of Paraíba, Department of Pharmacy, 58100-000, Campina Grande, PB, Brazil

关键词: Annonaceae;    Anaxagorea dolichocarpa;    azaphenanthrene alkaloid;    antitumor activity;   

DOI  :  10.3390/molecules16087125

来源: mdpi

【 摘 要 】

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC₅₀ of 18.97 and 10.95 µg/mL, respectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.