Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

Molecules

Tung-Ho Wu³  Yung-Yi Cheng⁵  Chao-Jung Chen⁴  Lean-Teik Ng⁶  Li-Chen Chou⁵  Li-Jiau Huang⁵  Yung-Husan Chen¹  Sheng-Chu Kuo⁵  Mohamed El-Shazly²  Yang-Chang Wu³  Fang-Rong Chang³ 

[1] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt; E-Mail:;Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mails:;Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan; E-Mail:;Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan; E-Mails:;Department of Agricultural Chemistry, National Taiwan University, Taipei 106, Taiwan; E-Mail:

关键词: clerodane diterpenes;    Polyalthia longifolia var. pendula;    Annonaceae;    anti-inflammatory;   

DOI  :  10.3390/molecules19022049

来源: mdpi

【 摘 要 】

Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)-methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (4–8). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13-dien-15-oic acid (7) showed promising NO inhibitory activity at 10 µg/mL, with 81.1% and 86.3%, inhibition, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.