Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida

Marine Drugs

Elkin Galeano²  Olivier P. Thomas³  Sara Robledo¹  Diana Munoz¹ 

[1] Program for the Study and Control of Tropical Diseases (PECET), University of Antioquia, Medellin AA 1226, Colombia; E-Mails:;Marine Natural Products Research Group, Pharmaceutical Chemistry Faculty, University of Antioquia, Medellin AA 1226, Colombia; E-Mail:;Chemical Institute of Nice, UMR 6001 CNRS, University of Nice—Sophia Antipolis, Parc Valrose, 06108, Nice Cedex 02, France; E-Mail:

关键词: bromotyrosines;    Verongula rigida;    antiplasmodial activity;    leishmanicidal activity;    trypanocidal activity;   

DOI  :  10.3390/md9101902

来源: mdpi

【 摘 要 】

Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 μM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed.

【 授权许可】

CC BY   
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