Química Nova | |
Antiparasitic bromotyrosine derivatives from the Caribbean marine sponge Aiolochroia crassa | |
Munoz, Diana1  Robledo, Sara1  Galeano, Elkin1  Thomas, Olivier P.1  University of Nice, Nice, France1  Martínez, Alejandro1  University of Antioquia, Medellin, Colombia1  | |
关键词: bromotyrosines; Aiolochroia crassa; antiparasitic activity.; | |
DOI : 10.1590/S0100-40422012000600023 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
Six bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Aiolochroia crassa: 3-bromo-5-hydroxy-O-methyltyrosine (1), 3-bromo-N,N,N-trimethyltyrosinium (2), 3-bromo-N,N,N,O-tetramethyltyrosinium (3), 3,5-dibromo-N,N,N-trimethyltyrosinium (4), 3,5-dibromo-N,N,N,O-tetramethyltyrosinium (5), and aeroplysinin-1 (6). Structural determination was performed using NMR, MS and comparison with literature data. All isolated compounds were screened for their in vitro activity against Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compound 4 showed selective antiparasitic activity against Leishmania and Plasmodium parasites. This is the first report of compounds 1, 4 and 5 in the sponge A. crassa and the first biological activity reports for compounds 2-4. This work shows that bromotyrosines are potential antiparasitic agents.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912050595765ZK.pdf | 237KB | download |