A Model of DNA Repeat-Assembled Mitotic Chromosomal Skeleton

Genes

关键词: repetitive DNA;    DNA repeats;    mitotic chromosome;    chromosomal skeleton;    repeat pairing;    chromatin;   

DOI  :  10.3390/genes2040661

来源: mdpi

【 摘 要 】

Despite intensive investigation for decades, the principle of higher-order organization of mitotic chromosomes is unclear. Here, I describe a novel model that emphasizes a critical role of interactions of homologous DNA repeats (repetitive elements; repetitive sequences) in mitotic chromosome architecture. According to the model, DNA repeats are assembled, via repeat interactions (pairing), into compact core structures that govern the arrangement of chromatins in mitotic chromosomes. Tandem repeat assemblies form a chromosomal axis to coordinate chromatins in the longitudinal dimension, while dispersed repeat assemblies form chromosomal nodes around the axis to organize chromatins in the halo. The chromosomal axis and nodes constitute a firm skeleton on which non-skeletal chromatins can be anchored, folded, and supercoiled.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.