Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl4-Induced Hepatic Damage

Molecules

Ruidong Li¹  Wenyuan Guo¹  Zhiren Fu¹  Guoshan Ding¹  You Zou¹ 

[1] Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China ^†These authors contributed equally to this work.

关键词: hepatoprotection;    rat;    carbon tetrachloride;    Radix Paeoniae Rubra;    antioxidant;   

DOI  :  10.3390/molecules16108684

来源: mdpi

【 摘 要 】

In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl₄)-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl₄-induced hepatotoxicity. The 20% CCl₄/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl₄-treated group were administered with CCl₄ twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl₄-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.