Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data

Marine Drugs

Narlize Silva Lira²  Ricardo Carneiro Montes²  Josean Fechine Tavares²  Marcelo Sobral da Silva²  Emidio V. L. da Cunha¹  Petronio Filgueiras de Athayde-Filho²  Luis Cezar Rodrigues²  Celidarque da Silva Dias² 

[1] Department of Pharmacy, State University of Paraiba, Campina Grande 58100-000, PB, Brazil; E-Mail:;Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil; E-Mails:

关键词: Aplysina;    marine sponges;    halogenated substances;    ¹³C NMR;    review;   

DOI  :  10.3390/md9112316

来源: mdpi

【 摘 要 】

Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their ¹³C NMR data is also part of the review. For this purpose 138 references were consulted.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland