Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Pharmaceutics

Mathieu S. Bolhuis¹  Prashant N. Panday²  Arianna D. Pranger²  Jos G. W. Kosterink² 

[1] Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands;

关键词: pharmacokinetics;    drug interaction;    antimicrobial drugs;    oxazolidinones;    rifamycines;    macrolides;    fluoroquinolones;    beta-lactams;    cytochrome P450;    induction;    inhibition;   

DOI  :  10.3390/pharmaceutics3040865

来源: mdpi

【 摘 要 】

Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.