Nanotechnology and Nanotoxicology in Retinopathy

International Journal of Molecular Sciences

Dong Hyun Jo¹  Tae Geol Lee² 

[1]Department of Ophthalmology, College of Medicine, Seoul National University, Seoul 110-744, Korea

[2] E-Mail:

[3]Center for Nano-Bio Technology, Division of Convergence Technology, Korea Research Institute of Standards and Science (KRISS), Daejon 305-340, Korea

[4] E-Mail:

关键词: blood-retinal barrier;    diabetic retinopathy;    macular degeneration;    nanoparticles;    retinal degeneration;    retinal diseases;    toxicology;    uveitis;   

DOI  :  10.3390/ijms12118288

来源: mdpi

【 摘 要 】

Nanoparticles are nanometer-scaled particles, and can be utilized in the form of nanocapsules, nanoconjugates, or nanoparticles themselves for the treatment of retinopathy, including angiogensis-related blindness, retinal degeneration, and uveitis. They are thought to improve the bioavailability in the retina and the permeability of therapeutic molecules across the barriers of the eye, such as the cornea, conjunctiva, and especially, blood-retinal barriers (BRBs). However, consisting of multiple neuronal cells, the retina can be the target of neuronal toxicity of nanoparticles, in common with the central and peripheral nervous system. Furthermore, the ability of nanoparticles to pass through the BRBs might increase the possibility of toxicity, simultaneously promoting distribution in the retinal layers. In this regard, we discussed nanotechnology and nanotoxicology in the treatment of retinopathy.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.