Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Pharmaceuticals

Hidetoshi Arima¹  Keiichi Motoyama² 

[1] id="af1-pharmaceuticals-05-00061">Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Jap

关键词: cyclodextrin;    polyamidoamine dendrimer;    conjugate;    siRNA delivery;    multifunction;   

DOI  :  10.3390/ph5010061

来源: mdpi

【 摘 要 】

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.