A New Triterpene from the Plant of Uncaria Macrophylla

Molecules

Guangli Sun¹  Xiaopo Zhang¹  Xudong Xu¹  Junshan Yang¹  Mingliang Zhong¹ 

[1] ¹Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China ²Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China ³Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China

关键词: triterpene;    3β;    6β;    19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester;    Uncaria macrophylla;    Rubiaceae;    antitumor activity;   

DOI  :  10.3390/molecules17010504

来源: mdpi

【 摘 要 】

Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.