A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

Molecules

Guangli Sun¹  Xiaopo Zhang¹  Xudong Xu¹  Junshan Yang¹  Mingliang Zhong¹ 

[1] ¹Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China ²Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China ³Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China

关键词: Uncaria macrophylla;    Rubiaceae;    3β;    6β;    19α-trihydroxy-12-oleanen-28-oic acid;    antitumor activity;   

DOI  :  10.3390/molecules17021883

来源: mdpi

【 摘 要 】

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (¹H-¹H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC₅₀ values of 78.2 µg/mL and 73.9 µg/mL.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.