Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

Marine Drugs

Mohamed-Elamir F. Hegazy²  Amira M. Gamal Eldeen³  Abdelaaty A. Shahat²  Fathy F. Abdel-Latif¹  Tarik A. Mohamed²  Bruce R. Whittlesey⁴ 

[1] Department of Chemistry, Faculty of Science, Minia University, El-Minia 61519, Egypt;Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt;Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Center, Dokki Cairo 12622, Egypt;Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA;

关键词: Sarcophyton glaucum;    soft coral;    diterpenes;    cancer chemo-preventive activity;   

DOI  :  10.3390/md10010209

来源: mdpi

【 摘 要 】

A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland