10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer

International Journal of Molecular Sciences

Chung-Yi Chen⁵  Kuo-Chen Cheng²  Andy Y Chang³  Ying-Ting Lin⁴  You-Cheng Hseu¹ 

[1] Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan; E-Mail:;Department of Biology, University of California, Riverside, Riverside, CA 92521, USA E-Mail:;Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail:;Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan; E-Mail:

关键词: ginger;    10-shogaol;    antioxidant activities;    skin cell;    proliferation;    growth factors;    migration;   

DOI  :  10.3390/ijms13021762

来源: mdpi

【 摘 要 】

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.