Sensors | |
Multi-Sensor Arrays for Online Monitoring of Cell Dynamics in |
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Pedro Mestres-Ventura1  Andrea Morguet1  | |
[1] Department of Anatomy and Cell Biology, Saarland University, University Hospital, Bldg. 61, 66421 Homburg, Saar, Germany; E-Mail: | |
关键词: sensor arrays; peri-cellular acidosis; cell respiration; cell adhesion; impedance; cell cultures; electron microscopy; choroid plexus; chick embryo; | |
DOI : 10.3390/s120201383 | |
来源: mdpi | |
【 摘 要 】
Sensors and multi-sensor arrays are the basis of new technologies for the non-label monitoring of cell activity. In this paper we show that choroid plexus cells can be cultured on silicon chips and that sensors register in real time changes in their activity, constituting an interesting experimental paradigm for cell biology and medical research. To validate the signals recorded (metabolism = peri-cellular acidification, oxygen consumption = respiration; impedance = adhesion, cell shape and motility) we performed experiments with compounds that act in a well-known way on cells, influencing these parameters. Our
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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RO202003190045979ZK.pdf | 1072KB | download |