Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26

Marine Drugs

Li Sun¹  Dongli Li¹  Meihua Tao¹  Yuchan Chen¹  Feijun Dan² 

[1] Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China;College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China;

关键词: pimarane diterpenes;    marine sediment-derived fungus;    Eutypella scoparia;    South China Sea;    cytotoxic activity;   

DOI  :  10.3390/md10030539

来源: mdpi

【 摘 要 】

Five new oxygenated pimarane diterpenes, named scopararanes C–G (1–5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1–5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1–5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.