Nutrients | |
Gender Different Response to Immunonutrition in Liver Cirrhosis with Sepsis in Rats | |
Tsann-Long Hwang1  | |
关键词: gender difference; immunonutrition; liver cirrhosis; sepsis; immunity; cecal ligation and puncture; sex hormone; | |
DOI : 10.3390/nu4030231 | |
来源: mdpi | |
【 摘 要 】
Females with sepsis have a better prognosis than males, while those of both genders with cirrhosis have a high mortality. Impaired immunity accompanies liver cirrhosis. The potential association between sex and immunologic response of cirrhotic rats in sepsis following immunonutrition was investigated. One hundred and forty-three rats were randomly divided into groups. Liver cirrhosis was produced by weekly feeding of CCl4 for 8 weeks. Among them, 24 male and 19 female underwent castration one month before studying. The rats were fed with either immune enhancing diet or control diet for five days, then sepsis was induced with cecal ligation and two holes puncture. Main outcomes included mortality and serum cytokines (IL-1β, 6, and 10). Comparisons were made both within and between genders. Cirrhotic non-castrated male rats showed a significant decrease in mortality (64.1%
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190045208ZK.pdf | 262KB | download |