Cancers | |
Micronutrient Synergy in the Fight against Hepatocellular Carcinoma | |
M. Waheed Roomi2  Nusrath W. Roomi2  Tatiana Kalinovsky2  Aleksandra Niedzwiecki1  | |
[1]Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA | |
关键词: hepatocellular carcinoma; HepG2; SK Hep-1; nutrient synergy; cell proliferation; MMPs; u-PA; TIMPs; matrigel invasion; apoptosis; | |
DOI : 10.3390/cancers4020323 | |
来源: mdpi | |
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【 摘 要 】
The incidence of hepatocellular carcinoma (HCC), once thought to be a rare tumor in North America, has rapidly increased in recent years in the United States. Current treatment modalities to halt the progression of this disease are only marginally effective. The mainstay treatment is liver transplantation, which is often confronted with donor shortage. Invasion, metastasis and recurrence contribute to the high mortality rate of this disease. Matrix metalloproteinases (MMPs) that degrade the extracellular matrix (ECM) have been associated with the progression, invasion and metastasis of the disease. We have developed strategies to strengthen the ECM collagen and inhibit MMPs through micronutrients such as lysine, proline and ascorbic acid. Addition of epigallocatechin gallate or green tea extract to these micronutrients synergistically enhanced anti-carcinogenic activity in HepG2 cells. Addition of certain other micronutrients, such as
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190045174ZK.pdf | 670KB | ![]() |