Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Molecules

Bendong Chen¹  Mingliang Ning² 

[1] Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China;Department of Oncological Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China

关键词: hepatocellular carcinoma;    paeonol;    oxidative injury;    immunity;    diethyl-nitrosamine;   

DOI  :  10.3390/molecules17044672

来源: mdpi

【 摘 要 】

The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.