Carcinogenesis and Metastasis in Liver: Cell Physiological Basis

Cancers

Vito Racanelli¹  Patrizia Leone¹  Gianmaria Miolo²  Anna Rossetto³  Matteo Cescon³  Matteo Ravaioli³  Valli De Re⁴  Agostino Steffan⁴  Alessandro Uzzau⁵  Umberto Baccarani⁶ 

[1]Department of Biomedical Sciences and Human Oncology, G. Baccelli Section of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy

[2]Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy

[3]Department of Organ Insufficiency and Transplantation, General Surgery and Transplantation, University Hospital of Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy

[4]Immunopatologia e Biomarcatori Oncologici/Bio-proteomics Facility, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy

[5]Program of Oncology Surgery, Dipartimento di Area Medica, University of Udine, 33100 Udine, Italy

[6]Surgery and Transplantation, Dipartimento di Area Medica, University of Udine, 33100 Udine, Italy

关键词: hepatocellular carcinoma;    nonalcoholic fatty liver disease;    nonalcoholic steatohepatitis;    hepatic stellate cells;    myofibroblasts;    vegf;    immunity;    circadian homeostasis;    cortisol;   

DOI  :  10.3390/cancers11111731

来源: DOAJ

【 摘 要 】

Hepatocellular carcinoma (HCC) incidence is rising. This paper summarises the current state of knowledge and recent discoveries in the cellular and physiological mechanisms leading to the development of liver cancer, especially HCC, and liver metastases. After reviewing normal hepatic cytoarchitecture and immunological characteristics, the paper addresses the pathophysiological factors that cause liver damage and predispose to neoplasia. Particular attention is given to chronic liver diseases, metabolic syndrome and the impact of altered gut microbiota, disrupted circadian rhythm and psychological stress. Improved knowledge of the multifactorial aetiology of HCC has important implications for the prevention and treatment of this cancer and of liver metastases in general.

【 授权许可】

Unknown