Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

Polymers

Yoshihiro Sasaki²  Setsuko Yamane³  Kei Kurosu²  Shin-Ichi Sawada¹ 

[1] Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan;Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan;Department of Chemistry and Biochemistry, Numazu National College of Technology, 3600 Ooka, Numazu 410-8501, Japan;

关键词: nanogel;    hydroxyapatite;    organic-inorganic hybrid;    calcium phosphate;   

DOI  :  10.3390/polym4021056

来源: mdpi

【 摘 要 】

Nanosized hydroxyapatite (HAp) materials have received much attention in the context of their advanced biomedical applications, including tissue engineering and drug delivery systems. Hybridization of nanosized HAp with organic molecules is a promising approach to facilitate the preparation of HAp nanomaterials. Here, templated mineralization using self-assembled nanogels modified with tricarboxylate groups was performed to yield the hybrid HAp nanomaterial. In the pH gradient method, the nanogel acted as an excellent template for the formation of well-dispersed HAp particles. Transmission electron microscopy, selected area electron diffraction patterns and energy-dispersive X-ray spectroscopy of these particles revealed that amorphous nanoparticles of amorphous calcium phosphate formed first, followed by transformation to crystalline hydroxyapatite.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.