Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices

Journal of Functional Biomaterials

Manuela Curcio¹  Giuseppe Cirillo²  Ortensia Ilaria Parisi²  Francesca Iemma²  Nevio Picci² 

[1] Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS) 87036, Italy;

关键词: molecularly imprinted polymers;    quercetin;    drug delivery;    cytotoxicity test;    nanomaterials;   

DOI  :  10.3390/jfb3020269

来源: mdpi

【 摘 要 】

In this work, molecularly imprinted nanospheres for controlled/sustained release of quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylate as functional monomer and crosslinking agent, respectively. One pot precipitation polymerization was chosen as polymerization technique to obtain nanosized materials with spherical shape. Morphological and hydrophilic properties by scanning electron microscopy and water content measurements were determined, and recognition and selectivity properties of the imprinted materials were tested using the template quercetin and its structural analogue, the flavonoid catechin. Finally, the applicability of the obtained materials as drug delivery devices was evaluated by performing in vitro release studies in plasma simulating fluids and cytotoxicity testson HeLa cells.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.