Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum

Marine Drugs

Tsun-Tai Yeh¹  Shang-Kwei Wang³  Chang-Feng Dai² 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan;;Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan

关键词: Briareum excavatum;    briarane-type diterpenoid;    cytotoxicity;    anti-HCMV;   

DOI  :  10.3390/md10051019

来源: mdpi

【 摘 要 】

In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.