Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Polymers

Gabriele Giani¹  Serena Fedi¹ 

[1] Centro Interuniversitario Sistemi Medici Avanzati (C.R.I.S.M.A.), Colle di Val d’Elsa Viale Matteotti 15, Siena, 53034 Colle di Val d’Elsa, Italy;

关键词: magnetic nanoparticles;    magnetic hydrogel;    functionalization of nanoparticles;    voltammetry analysis of nanoparticles;    AFM analysis;   

DOI  :  10.3390/polym4021157

来源: mdpi

【 摘 要 】

Novel hybrid magnetic hydrogels have demonstrated their influence in several areas, particularly in biomedical science where these innovative materials are showing interesting applications for controlled drug delivery. A hybrid hydrogel with CoFe₂O₄ nanoparticles (NPs) as cross-linker agents of carboxymethylcellulose (CMC) polymer was obtained with the aim of testing it as a system for controlled drug release. The NPs were functionalized with (3-aminopropyl)-trimethoxysilane (APTMS) in order to introduce-NH₂ groups on the surface. Infrared spectroscopy, XPS and electrochemical analysis were performed to quantify the amino coating. The presence of magnetic nanoparticles makes the system suitable for an application with magnetic stimulus. Preliminary studies performed with alternating magnetic fields indicate a release of the drug-like molecules previously loaded in the matrix.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.