Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Molecules

Jing-Jing Xia¹ 

[1] School of Materials and Chemical Engineering, Anhui University of Architecture, Hefei 230601, China

关键词: acridinedione;    polyhydroquinoline;    one-pot reaction;    water;   

DOI  :  10.3390/molecules17055339

来源: mdpi

【 摘 要 】

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.