Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

Applied Sciences

Cosmas O. Okoro¹  Mumiye A. Ogunwale² 

[1] Department of Chemistry, Tennessee State University, Nashville, TN 37209, USA;

关键词: unsymmetric Hantzsch reaction;    dihydropyridine;    trifluoromethyl;    hexahydroquinoline;    acridinedione;    trifluoroethanol;   

DOI  :  10.3390/app2020368

来源: mdpi

【 摘 要 】

This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yield.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.