Tropical Plant Extracts as Potential Antihyperglycemic Agents

Molecules

Thamilvaani Manaharan¹  Uma Devi Palanisamy¹ 

[1] ¹Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia ²School of Medicine and Health Sciences, Monash University, Sunway Campus, Bandar Sunway, Selangor 46150, Malaysia

关键词: type 2 diabetes mellitus;    a-glucosidase;    a-amylase;    antioxidant;    total phenolic content;   

DOI  :  10.3390/molecules17055915

来源: mdpi

【 摘 要 】

Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, a-amylase and a-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.