α-Anilinoketones, Esters and Amides: A Chemical Study

Pharmaceuticals

Amjad M. Qandil¹ 

[1] Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan

关键词: α-anilinoketones;    2-anilinoalcohols;    α-anilinoesters;    α-haloketones;    intramolecular hydrogen bond;   

DOI  :  10.3390/ph5060591

来源: mdpi

【 摘 要 】

A group of α-anilinoketones, 2-aminoalcohols, α-anilinoesters and α-anilinoamides were successfully synthesized and characterized by NMR spectroscopy and mass spectrometry. The yields were, in general, moderate to good (up to 75.4%), except for the α-anilinoesters (16.9–35.6%). The α-halocarbonyl starting materials showed different chemical reactivities. α-Haloketones and α-chloroacetates afforded monoalkylation, while small α-chloroamides afforded dialkylation. Finally, NMR spectroscopy revealed interesting structural features about the 2-aminoalcohols and diphenylamides.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.