Catalyst: and solvent-free synthesis of imidazo[1,2-a]pyridines

Journal of the Brazilian Chemical Society

Zhu, Dong-Jian¹  Wenzhou University, Wenzhou, China¹  Wenzhou Vocational and Technical College, Wenzhou, China¹  Wu, Hua-Yue¹  Ding, Jin-Chang¹  Liu, Miao-Chang¹  Chen, Jiu-Xi¹ 

关键词: imidazo[1;    2-a]pyridines;    α-haloketones;    2-aminopyridines;    catalyst-free;    solvent-free;   

DOI  :  10.1590/S0103-50532009000300012

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A highly efficient and facile method has been described for the synthesis of imidazo[1,2-a]pyridines in good to excellent yields by condensation of the α-haloketones (ArCOCHXR2, Ar = C6H5, 4-MeOC6H4, 4-ClC6H4, 2,4-Cl2C6H3; X = Br, Cl; R2 = H, CH3) with 2-aminopyridines without the use of any additional catalyst and solvent.

【 授权许可】

Unknown