International Journal of Molecular Sciences | |
The Kiss-and-Run Model of Intra-Golgi Transport | |
Alexander A. Mironov1  | |
关键词: intra-Golgi transport; Golgi apparatus; vesicular model; cisterna maturation; kiss-and-run model; | |
DOI : 10.3390/ijms13066800 | |
来源: mdpi | |
【 摘 要 】
The Golgi apparatus (GA) is the main station along the secretory pathway. Mechanisms of intra-Golgi transport remain unresolved. Three models compete with each other for the right to be defined as the paradigm. The vesicular model cannot explain the following: (1) lipid droplets and aggregates of procollagen that are larger than coatomer I (COPI)-dependent vesicles are transported across the GA; and (2) most anterograde cargoes are depleted in COPI vesicles. The compartment progression/maturation model has the following problems: (1) most Golgi-resident proteins are depleted in COPI vesicles; (2) there are no COPI vesicles for the recycling of the resident proteins in the
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190044158ZK.pdf | 230KB | download |