Morphological Features of Organelles during Apoptosis: An Overview

Cells

Maria Grazia Bottone²  Giada Santin²  Francesca Aredia¹  Graziella Bernocchi²  Carlo Pellicciari² 

[1] Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy; E-Mail:;Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie “L. Spallanzani”, Università di Pavia, 27100 Pavia, Italy; E-Mails:

关键词: apoptosis;    cytoskeleton;    endoplasmic reticulum;    Golgi apparatus;    lysosomes;    mitochondria;   

DOI  :  10.3390/cells2020294

来源: mdpi

【 摘 要 】

An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.