Breakdown of the Blood-Ocular Barrier as a Strategy for the Systemic Use of Nanosystems

Pharmaceutics

Marcelo L. Occhiutto¹  Fatima R. Freitas¹  Raul C. Maranhao¹ 

[1] Heart Institute, Medical School Hospital, University of São Paulo, São Paulo 05403-000, Brazil;

关键词: blood-ocular barrier;    hypotony;    nanotechnology;    ocular drug delivery system;    ocular inflammatory mediators;    systemic route;   

DOI  :  10.3390/pharmaceutics4020252

来源: mdpi

【 摘 要 】

Several drug delivery systems have been proposed to overcome physiological barriers, improving ocular bioavailability. Systemic routes are seldom used due to the blood-ocular barrier. Novel drug delivery systems based on nanotechnology techniques have been developed to overcome ocular physiological barriers. This non-systematic review suggests the utilization of a transitory blood-ocular breakdown to allow the access of drugs by nanotechnology drug delivery systems via the systemic route. We discuss the possible ways to cause the breakdown of the blood-ocular barrier: acute inflammation caused by intraocular surgery, induced ocular hypotony, and the use of inflammatory mediators. The suitability of use of the systemic route and its toxic effects are also discussed in this article.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.