Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment

Journal of Functional Biomaterials

Francesco Puoci³  Cristiana Piangiolino²  Francesco Givigliano¹  Ortensia Ilaria Parisi³  Roberta Cassano³  Sonia Trombino³  Manuela Curcio³  Francesca Iemma³  Giuseppe Cirillo³  Umile Gianfranco Spizzirri³  Donatella Restuccia³  Rita Muzzalupo³ 

[1] Department of Thoracic Surgery, Policlinico Universitario Germaneto-Fondazione Tommaso Campanella, Campus Universitario “Salvatore Venuta” Viale Europa, Località Germaneto 88100, Italy;Principium Europe, Via Como 45, Solaro (MI) 20020, Italy;Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy;

关键词: protein;    ciprofloxacin;    quinolones;    biomedical application;    antibiotic;    antimicrobial;    infection;    wound healing;    fibroblast proliferation;   

DOI  :  10.3390/jfb3020361

来源: mdpi

【 摘 要 】

The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.