Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated from Artocarpus obtusus F.M. Jarrett

Molecules

Najihah Mohd. Hashim¹  Mawardi Rahmani¹  Gwendoline Cheng Lian Ee¹  Mohd Aspollah Sukari¹  Maizatulakmal Yahayu¹  Muhamad Aizat Mohd Amin¹  Abd Manaf Ali¹ 

[1] ¹Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia

关键词: antimicrobial;    antioxidant;    antiproliferative;    Artocarpus obtusus;    pyranocycloartobiloxanthone A;    tyrosinase inhibitory;   

DOI  :  10.3390/molecules17056071

来源: mdpi

【 摘 要 】

One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC₅₀ value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.

【 授权许可】

CC BY   
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