Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne

Molecules

Jieru Guo¹  Jinwen Zhang¹  Penghua Shu¹  Lingmei Kong¹  Xincai Hao¹  Yongbo Xue¹  Zengwei Luo¹  Yan Li¹  Gao Li¹  Guangmin Yao¹ 

[1] ¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

关键词: Wikstroemia chamaedaphne;    diterpenoids;    lignans;    cytotoxicity;   

DOI  :  10.3390/molecules17066424

来源: mdpi

【 摘 要 】

Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P₂ (2), P₃ (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.