Evaluation of the Antioxidant Capacity of Synthesized Coumarins

International Journal of Molecular Sciences

Damiana R. Vianna¹  Guilherme Bubols¹  Gabriela Meirelles¹  Bárbara V. Silva²  Alessandra da Rocha³  Maurໜio Lanznaster⁴  José Maria Monserrat³  Solange Cristina Garcia¹  Gilsane von Poser¹ 

[1] Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil; E-Mails:;Institute of Chemistry, Federal University of Rio de Janeiro, UFRJ, Bloco A, Cidade Universitária, 21941-909, Rio de Janeiro, RJ, Brazil; E-Mail:;Post-Graduate Program in Physiological Sciences, Comparative Animal Physiology, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Av Itália km 8 s/n, 96201-900, Rio Grande, RS, Brazil; E-Mails:;Institute of Chemistry, Universidade Federal Fluminense, UFF, Outeiro de São João Batista, s/n, Campus do Valonguinho Centro, 24020-150, Niterói, RJ, Brazil; E-Mail:

关键词: antioxidant capacity;    peroxyl radicals;    coumarins;    DPPH;    cyclic voltammetry;   

DOI  :  10.3390/ijms13067260

来源: mdpi

【 摘 要 】

Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH^•) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.