New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea

Marine Drugs

Jiun-Yang Chang¹  Chia-Ching Liaw¹  Ahmed Eid Fazary¹  Tsong-Long Hwang² 

[1] School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 101-200, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;

关键词: Junceella juncea;    briaranes;    anti-inflammatory activity;   

DOI  :  10.3390/md10061321

来源: mdpi

【 摘 要 】

Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.