Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst

Molecules

Hyun Joo Lee¹  Saet Byeol Woo¹ 

[1] Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Korea

关键词: oxindole;    methyl vinyl ketone;    conjugate addition;    bifunctional organocatalysis;    asymmetric catalysis;   

DOI  :  10.3390/molecules17067523

来源: mdpi

【 摘 要 】

The enantioselective conjugate addition reaction of 3-aryl-substituted oxindoles with methyl vinyl ketone promoted by binaphthyl-modified bifunctional organocatalysts was investigated. The corresponding Michael adducts, containing a quaternary center at the C3-position of the oxindoles, were generally obtained in high yields with excellent enantioselectivities (up to 91% ee).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.