Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins

Cells

Stéphane Demine¹  Sstien Michel¹  Kayleen Vannuvel¹  Anaïs Wanet¹  Patricia Renard¹ 

[1] Laboratory of Biochemistry and Cell Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000, Belgium;

关键词: mitophagy;    lipophagy;    specific autophagy;    organelle dysfunction;    triglyceride accumulation;    protein secretion;   

DOI  :  10.3390/cells1020168

来源: mdpi

【 摘 要 】

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.