Pharmacological Evaluation of LiuWei Zhuanggu Granules in Rats

Molecules

Haiming Zhu¹  Liang Ding¹  Haijun Xiao¹  Weifeng Ni¹  Feng Xue¹ 

[1] Department of Orthopaedic Surgery, Shanghai Fengxian Central Hospital, No. 9588, NanFeng Road, Fengxian District, Shanghai 201400, China

关键词: LWZGG;    Ca;    Zn;    Cu;    CT;    BGP;    uterine;   

DOI  :  10.3390/molecules17078001

来源: mdpi

【 摘 要 】

Many commonly consumed foods, herbs and spices contain a complex array of naturally occurring bioactive molecules called phytochemicals, which may confer health benefits. In this study, the impact of LiuWei Zhuanggu Granules (LWZGG) on mineral metabolism in osteopenia development was evaluated. Results showed that serum estrogen, bone gla protein (BGP), and calcitonin (CT) levels, bone Ca, Zn and Cu levels, femur, lumbar vertebrae and trabecular bone density, tibia maximum stress and maximum bending strength were increased, and serum parathyroid hormone (PTH), serum and urine Ca, Zn and Cu levels were decreased in rat bone. It can be concluded that LWZGG is useful to improve bone quality in ovariectomized (OVX) rats.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.