Herpesvirus Exploitation of Host Immune Inhibitory Pathways

Viruses

Gabrielle Stack¹  Maria A. Stacey¹ 

[1] Institute of Infection and Immunity, Cardiff University, Cardiff, CF14 4XN, UK;

关键词: herpesvirus;    immune suppression;    IL-10;    CD200;    PD-1;    BTLA;    cytomegalovirus;   

DOI  :  10.3390/v4081182

来源: mdpi

【 摘 要 】

Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.