Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

International Journal of Molecular Sciences

Hong Zhuang²  Zhi Wang¹  Jiaxin Wang¹  Hong Zhang¹  Erna Xun¹  Ge Chen¹  Hong Yue¹  Ning Tang² 

[1] Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130021, China; E-Mails:;Department of Food Science and Engineering, Jilin University, Changchun 130021, China; E-Mails:

关键词: triptorelin lactate;    lipase;    enzyme activity;    esterification;   

DOI  :  10.3390/ijms13089971

来源: mdpi

【 摘 要 】

Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.