Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor

Sensors

Zin-Sig Kim¹  Sang Chul Lim¹  Seong Hyun Kim¹  Yong Suk Yang¹ 

[1] Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea; E-Mails:

关键词: biosensor;    F8T2;    organic semiconductor;    fluorescence;    OTFT;    biotin;    avidin;   

DOI  :  10.3390/s120811238

来源: mdpi

【 摘 要 】

This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.