The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside

Molecules

Toshiyuki Hamada²  Yohann White³  Mitsuyoshi Nakashima²  Yusuke Oiso²  Masaki J. Fujita¹  Hiroaki Okamura²  Tetsuo Iwagawa² 

[1] Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 860-8555, Japan;Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan;Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

关键词: ATL;    bioassay-guided isolation;    S1T;    growth inhibitor;    lignan;    NMR;    structure;   

DOI  :  10.3390/molecules17089931

来源: mdpi

【 摘 要 】

Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.