Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

Molecules

Carlos Barea³  Adriana Pabón¹  Silvia Galiano³  Silvia Pérez-Silanes³  German Gonzalez²  Chloe Deyssard²  Antonio Monge³  Eric Deharo² 

[1] Malaria Group, University of Antioquia, Medellín, Colombia;UMR 152 PharmaDev (Pharmacologie et Pharmacochimie pour le Développement), Université de Toulouse, UPS, 118, rte de Narbonne, F-31062 Toulouse cedex 9, France;Research and Development of Novel Drugs Unit, Center for Applied Pharmacobiology Research (CIFA), University of Navarre, Pamplona 31080, Spain;

关键词: quinoxaline;    piperazine;    Plasmodium;    Leishmania;    VERO;   

DOI  :  10.3390/molecules17089451

来源: mdpi

【 摘 要 】

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.