Fully Integrated Biochip Platforms for Advanced Healthcare

Sensors

Sandro Carrara¹  Sara Ghoreishizadeh¹  Jacopo Olivo¹  Irene Taurino¹  Camilla Baj-Rossi¹  Andrea Cavallini¹  Maaike Op de Beeck²  Catherine Dehollain¹  Wayne Burleson⁵  Francis Gabriel Moussy⁴  Anthony Guiseppi-Elie³ 

[1] École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland; E-Mails:;Interuniversity Microelectronics Centre (IMEC), B-3001 Leuven, Belgium; E-Mail:;Department of Electrical and Computer Engineering, Center for Bioelectronics, Biosensors and Biochips, Clemson University, Anderson, SC 29625, USA; E-Mail:;Brunel Institute for Bioengineering, University of Brunel, West London, UB8 3PH, UK; E-Mail:;Department of Electrical and Computer Engineering, University of Massachusetts, Amherst, MA 01003, USA; E-Mail:

关键词: biochip;    CMOS design;    enzymes;    biotechnology;    nanotechnology;    potentiostats;    biocompatible membranes;    security;    privacy;    remote powering;   

DOI  :  10.3390/s120811013

来源: mdpi

【 摘 要 】

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.