Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

Marine Drugs

Tomohiro Osaki¹  Kazuo Azuma¹  Seiji Kurozumi²  Yoshimori Takamori²  Takeshi Tsuka¹  Tomohiro Imagawa¹  Yoshiharu Okamoto¹ 

[1] Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan;Koyo Chemical Co. Ltd., 3-11-15 Iidabashi, Chiyodaku, Tokyo 102-0072, Japan;

关键词: amino acid;    dog;    glucosamine hydrochloride;    metabolomic analyses;   

DOI  :  10.3390/md10081873

来源: mdpi

【 摘 要 】

D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.