A microRNA Link to Glioblastoma Heterogeneity

Cancers

Sanjay K. Singh¹  Alenoush Vartanian¹  Kelly Burrell¹ 

[1] The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1L7, Canada;

关键词: glioma;    glioblastoma;    microRNA;    angiogenesis;    glioma stem cells;    metabolism;    Warburg effect;   

DOI  :  10.3390/cancers4030846

来源: mdpi

【 摘 要 】

Glioblastomas (GBM) are one of the most malignant adult primary brain tumors. Through decades of research using various model systems and GBM patients, we have gained considerable insights into the mechanisms regulating GBM pathogenesis, but have mostly failed to significantly improve clinical outcome. For the most part GBM heterogeneity is responsible for this lack of progress. Here, we have discussed sources of cellular and microenvironmental heterogeneity in GBMs and their potential regulation through microRNA mediated mechanisms. We have focused on the role of individual microRNAs (miRNA) through their specific targets and miRNA mediated RNA-RNA interaction networks with the potential to influence various aspects of GBM heterogeneity including tumor neo-vascularization. We believe a better understanding of such mechanisms for regulation of GBM pathogenesis will be instrumental for future therapeutic options.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.