New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

International Journal of Molecular Sciences

Waqar Ahmad Kaleem¹  Muhammad Nisar³  Mughal Qayum⁵  Muhammad Zia-Ul-Haq²  Achyut Adhikari⁴ 

[1] Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan; E-Mail:;Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan; E-Mail:;Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan; E-Mail:;H.E.J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi 75270, Pakistan; E-Mail:;Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat 2600, Pakistan; E-Mail:

关键词: Zizyphus oxyphylla Edgew;    cyclopeptide alkaloids;    antibacterial activity;   

DOI  :  10.3390/ijms130911520

来源: mdpi

【 摘 要 】

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.